The concentration and surface chemistry of our gold nanoparticles are ideal to be used with the protocol developed by the Mirkin group for the high-density conjugation to nucleic acids (see references below).
Product Data Sheet and Protocol
Safety Data Sheet
- H. D. Hill & C. A. Mirkin. The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange. Nature Protocols, 2006, 1, 324–336. (link)
- X. Chen, F. Lisi, P. Bakthavathsalam, G. Longatte, S. Hoque, R. D. Tilley, J. J. Gooding. Impact of the Coverage of Aptamers on a Nanoparticle on the Binding Equilibrium and Kinetics between Aptamer and Protein. ACS sensors, 2020, 2021, 6, 2, 538–545. (link)