The squarate-PEG6-BCN is a linear heterobifunctional PEG reagent with a bicyclononyne (BCN) group that can react with azide groups without the need for metal catalysis. The ethyl squaramate group reacts with amines and, compared with the standard N-hydroxysuccinimide (NHS), is much less prone to hydrolysis, which yields higher protein-conjugation efficiency in aqueous medium.
Product Data Sheet and Protocol
Safety Data Sheet
- C. Schieber, A. Bestetti, J. P. Lim, A. D. Ryan, T.‐L. Nguyen, R Eldridge, A. R. White, P. A. Gleeson, P. S. Donnelly, S. J. Williams, P. Mulvaney. Conjugation of Transferrin to Azide‐Modified CdSe/ZnS Core–Shell Quantum Dots using Cyclooctyne Click Chemistry, Angew. Chem. Int. Ed., 2012, 51, 10523-10527. (link)